We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Prooxidant-Antioxidant Balance and Antioxidized LDL Antibody Level Values and Cardiac Function in Patients with Coronary Artery Disease.
- Authors
Rahsepar, Amir Ali; Mirzaee, Asadollah; Moodi, Fatemeh; Moohebati, Mohsen; Tavallaie, Shima; Eshraghi, Ali; Alavi, Maryam-Sadat; Khorashadizadeh, Fatemeh; Pourghadamyari, Hossein; Paydar, Roghayeh; Amini, Maral; Khojasteh, Roshanak; Mousavi, Somayeh; Sahebi, Maryam; Ghayour-Mobarhan, Majid; Ferns, Gordon A.A.
- Abstract
Objectives: We studied the association between the prooxidant-antioxidant balance (PAB), anti-malondialdehyde-modified low-density lipoprotein (oxidized LDL, ox-LDL) IgG antibody and indices of cardiac function (systolic and diastolic function) in patients with coronary artery disease (CAD). Methods: Fifty-five patients with established CAD were selected, and serum levels of anti-ox-LDL IgG and PAB values were measured and compared with 40 matched healthy controls. Systolic and diastolic functions were determined for all patients. Results: PAB values were significantly higher in patients than in controls (p < 0.001), whilst serum anti-ox-LDL concentrations were not statistically different between the 2 groups (p = 0.821). However, after adjustment for high-density lipoprotein cholesterol, the patients had higher anti-ox-LDL levels (p = 0.04). Total PAB values were inversely associated with ejection fraction (r = -0.326, p = 0.031), but this was not the case for anti-ox-LDL in either group (p > 0.05). Conclusion: Serum concentrations of a marker of oxidative stress (PAB values) are inversely associated with cardiac function. PAB is a relatively simple index that could be incorporated into risk assessment in CAD patients. Anti-ox-LDL IgG antibody concentration does not appear to reflect total oxidative stress as assessed by PAB. Copyright © 2012 S. Karger AG, Basel
- Subjects
ANTIOXIDANTS; LOW density lipoproteins; IMMUNOGLOBULINS; CORONARY disease; OXIDATIVE stress; HEALTH risk assessment; PATIENTS
- Publication
Cardiology, 2012, Vol 122, Issue 4, p203
- ISSN
0008-6312
- Publication type
Article
- DOI
10.1159/000339273