We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Secondary Metabolites from the Mangroves-Derived Streptomyces sp. Scsio 41396 and Their Anti-Enzyme Activity.
- Authors
Yuan, Yuan; Zhao, Kai; Hu, Yiwei; Liu, Yonghong; Liu, Qingchao; Wang, Junfeng
- Abstract
This article discusses the secondary metabolites derived from Streptomyces sp. Scsio 41396, a strain of bacteria found in mangrove soil. The researchers isolated and purified seven compounds using chromatography and evaluated their inhibitory activities against pancreatic lipase, acetylcholinesterase, and neuraminidase. Compound 1 showed strong inhibitory activity against neuraminidase and notable inhibitory activity against pancreatic lipase, while compound 3 displayed significant inhibitory activity against pancreatic lipase. The article provides detailed information about the extraction, isolation, and identification of the compounds, as well as their chemical properties and inhibitory activities. Molecular docking studies revealed the interactions of compound 1 with specific amino acid residues in the active site of neuraminidase. The research was supported by grants and the authors acknowledged the assistance of individuals in recording spectroscopic data.
- Subjects
METABOLITES; NEURAMINIDASE; STREPTOMYCES
- Publication
Chemistry of Natural Compounds, 2024, Vol 60, Issue 3, p523
- ISSN
0009-3130
- Publication type
Article
- DOI
10.1007/s10600-024-04369-5