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- Title
Gold Nanorods with Organosilica Shells as a Platform for Creating Multifunctional Nanostructures.
- Authors
Salavatov, N. A.; Dement'eva, O. V.; Rudoy, V. M.
- Abstract
The perspectives of using γ-mercaptopropyltrimethoxysilane as a precursor for creating multifunctional composite nanoparticles (CNPs) with a rodlike gold core and an organosilica shell have been analyzed. It is shown that the presence of thiol groups, which are capable of specific interactions with metal ions and atoms, in the shell makes it possible to "directly" (i.e., without any additional modification) load rather large amounts of an anticancer drug, cisplatin, into it. In addition, preliminary data have been obtained that indicate the possibility of nitrosation of the SH-groups of the shells, which is very important from the viewpoint of creating container CNPs for NO, with such containers providing not only its delivery to tumors, but also its controlled release under the action of laser radiation.
- Subjects
NANORODS; LASER beams; NANOSTRUCTURES; SULFHYDRYL group; GOLD nanoparticles
- Publication
Colloid Journal, 2020, Vol 82, Issue 6, p713
- ISSN
1061-933X
- Publication type
Article
- DOI
10.1134/S1061933X20060125