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- Title
Protection of the ischaemic myocardium by Na<sup>+</sup>/H<sup>+</sup> exchange inhibitors: potential mechanisms of action.
- Authors
Avkiran, Metin
- Abstract
The article focuses on the cellular mechanisms through which sodium/hydrogen exchanger (NHE) inhibitors may preserve myocardial integrity and function during ischaemia and reperfusion. Increased sarcolemmal NHE activity, arising from the rapid normalisation of extracellular pH. During a prolonged period of ischaemia, NHE activity would be expected to be high soon after the onset of ischaemia. The rapid normalization of extracellular pH during early reperfusion would be expected to disinhibit the sarcolemmal NHE and lead to further injury.
- Subjects
ISCHEMIA; REPERFUSION injury; SARCOLEMMA; PH effect; BLOOD circulation disorders; COMPARTMENT syndrome
- Publication
Basic Research in Cardiology, 2001, Vol 96, Issue 4, p306
- ISSN
0300-8428
- Publication type
Article
- DOI
10.1007/s003950170037