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- Title
D152 树脂对多粘菌素E的提取性能研究.
- Authors
赵振中; 李海超
- Abstract
Polymyxin E is produced by fermentation of Bacillus polymyxa. It was usually purified by ion exchange. The extraction indexes of polymyxin E by D152 (weak acid cation resin) was studied, and the adsorption capacity, elution rate and yield of polymyxin E were obtained by matching D152 resin with the existing process equipment. The adsorption capacity of D152 resin can reach 6. 8X106 U/mL (wet resin), and the total yield is >98.0% under the pH of polymyxin E filtrate in 6.0~7.0, the chromatotiter in 3. 0X105 U/mL, the adsorption velocity of 1.0 BV/h and sulfuric acid elution velocity of 1.0~1. 5 BV/h under the chromatofiter was adsorbed by three columns in series. After 6 months of continuous operation, D152 resin has stable performance.
- Publication
Uranium Mining & Metallurgy, 2023, Vol 42, Issue 3, p63
- ISSN
1000-8063
- Publication type
Article
- DOI
10.13426/j.cnki.yky2023.03.10