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- Title
Lanthanum hydroxide inhibits vascular calcification by regulating the HIF‐1 pathway.
- Authors
Wang, Shengnan; Zhao, Lulu; Liu, Hong; Han, Ruilan; Liu, Yang; Gao, Jie; Bu, Ren; Li, Bing; Sun, Lijun; Hao, Jian; Zhao, Jianrong; Li, Gang
- Abstract
The main reason for the high incidence of cardiovascular disease in chronic kidney disease (CKD) patients with vascular calcification (VC) is also the main cause of death in CKD patients. Lanthanum hydroxide (LH) has an inhibitory effect on VC in chronic renal failure; however, the mechanism of its inhibition is poorly defined. Here, we used network pharmacology analysis and found that hypoxia‐inducible factor (HIF) is related to VC. In a CKD rat model induced by adenine combined with high phosphorus (1.2%), LH improved the survival rate and inhibited the occurrence and development of VC. In an in vitro study, we found that lanthanum chloride inhibited the occurrence of VC induced by high phosphorus and reduced the production of reactive oxygen species. This study thus revealed that LH can inhibit the occurrence and development of VC by inhibiting the activation of HIF‐1.
- Subjects
ARTERIAL calcification; LANTHANUM; CHRONIC kidney failure; HYPOXIA-inducible factors; HYDROXIDES
- Publication
Cell Biology International, 2022, Vol 46, Issue 8, p1275
- ISSN
1065-6995
- Publication type
Article
- DOI
10.1002/cbin.11811