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- Title
Genomic analysis and transcriptomic response to uranium stress of Stenotrophomonas maltophilia H002.
- Authors
TANG Ting; LI Wen-Jin; LI Rui; FENG Hong
- Abstract
To explore the molecular mechanism of Stenotrophomonas maltophilia H002 in response to metal uranium impact and the potential of bioremediation of uranium pollution, genome and transcrip- tome analyses were performed in this study. It was shown that the H002 genome consists of 5 099 056 bp to encode 4780 proteins. Compared with the 6 homologous strains, H002 encodes 344 unique proteins, mainly involved in membrane transport, cell motility and secretion. Transcriptome analysis revealed that in the early stage (1 h) of uranium stress, the differentially expressed genes were mainly enriched in KEGG pathways such as cell mobility and secretion, the biosynthesis of protein and peptidogly-can. The downregulation of partial secretion channel-related genes may reduce the absorption of uranium ions, hence decreasing cellular toxicity. In the later stage (2 h and 4 h) of uranium stress, upregulation of the genes encoding phosphatases involved in uranium mineralization and the cytochrome c proteins, which can provide the reducing electronics, may help reduce the toxicity to the cells.
- Subjects
GENOMICS; STENOTROPHOMONAS maltophilia; URANIUM; BIOLOGICAL transport; TRANSCRIPTOMES; CYTOCHROME c
- Publication
Journal Of Sichuan University (Natural Sciences Division) / Sichuan Daxue Xuebao-Ziran Kexueban, 2023, Vol 60, Issue 6, p1
- ISSN
0490-6756
- Publication type
Article
- DOI
10.19907/j.0490-6756.2023.066003