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- Title
Asthma-like symptoms in the first year of life and health-related quality of life at age 12 months: the Generation R study.
- Authors
Mohangoo AD; de Koning HJ; de Jongste JC; Landgraf JM; van der Wouden JC; Jaddoe VW; Hofman A; Moll HA; Mackenbach JP; Raat H; Mohangoo, Ashna D; de Koning, Harry J; de Jongste, Johan C; Landgraf, Jeanne M; van der Wouden, Johannes C; Jaddoe, Vincent W V; Hofman, Albert; Moll, Henriette A; Mackenbach, Johan P; Raat, Hein
- Abstract
<bold>Purpose: </bold>This study compares HRQOL among subgroups of infants with asthma-like symptoms to a subgroup without such symptoms and examines independent associations between asthma-like symptoms during the first year of life and HRQOL at age 12 months.<bold>Methods: </bold>Our study sample included 5,000 infants participating in the Generation R study. Their parents completed structured questionnaires to obtain information on asthma-like symptoms, HRQOL, infants', and maternal characteristics. Asthma-like symptoms were defined according to the number of positive answers to 12 items on lower respiratory symptoms. HRQOL was measured using the ITQOL. Higher scores indicated better HRQOL.<bold>Results: </bold>Infants with asthma-like symptoms had significantly lower HRQOL scores for all ITQOL scales. Among the subgroup with severe symptoms (4% of the infants), relevant deficits in HRQOL were observed for most ITQOL scales, particularly for General Health, Bodily Pain, and Family Activities (effect sizes ≥ 0.8). In multivariate linear models, asthma-like symptoms were independently associated with 6 ITQOL scales. The population attributable risks were especially high for Family Activities, General Health, Parental Emotional, and Parental Time.<bold>Conclusions: </bold>Asthma-like symptoms during the first year of life are associated with impaired quality of life at age 12 months. At population level, asthma-like symptoms were associated with lower HRQOL, regardless of symptom severity.
- Publication
Quality of Life Research, 2012, Vol 21, Issue 3, p545
- ISSN
0962-9343
- Publication type
journal article
- DOI
10.1007/s11136-011-9957-9