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- Title
The paradox of platypnoea–orthodeoxia syndrome.
- Authors
Leaver, Benjamin A.; Cliff, Edward R. S.; Jefford, Michael; Fogarty, Samuel; Zentner, Dominica
- Abstract
Platypnoea–orthodeoxia is a rare clinical syndrome characterised by dyspnoea and oxygen desaturation in the upright position which improves when supine. It requires two components: a sufficiently sized anatomical vascular defect (typically intra‐cardiac or intra‐pulmonary) combined with a functional component that promotes positional right‐to‐left shunting. We describe the rare occurrence of a patient with platypnoea–orthodeoxia syndrome (POS) because of a paradoxical shunt through a patent foramen ovale caused by a large right atrial line‐associated thrombus in a male with metastatic oesophageal cancer undergoing chemotherapy. This case is a timely reminder to consider POS amongst differentials for hypoxia as it is often treatable if recognised.
- Subjects
ADENOCARCINOMA; COMBINATION drug therapy; IRINOTECAN; PLATYPNEA orthodeoxia syndrome; CISPLATIN; LOW-molecular-weight heparin; CORONARY thrombosis; COMPUTED tomography; SURGICAL anastomosis; ESOPHAGEAL tumors; ATRIAL septal defects; CANCER chemotherapy; ENOXAPARIN; FOLINIC acid; OXALIPLATIN; DYSPNEA; FLUOROURACIL; DISEASE progression; DEXAMETHASONE; HYPOXEMIA
- Publication
Internal Medicine Journal, 2024, Vol 54, Issue 4, p675
- ISSN
1444-0903
- Publication type
Article
- DOI
10.1111/imj.16365