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- Title
Bioinformatics analysis of the prognostic value of Tripartite Motif 28 in breast cancer.
- Authors
LING HAO; JUN LENG; RUIJING XIAO; TEMBO KINGSLEY; XINRAN LI; ZHENBO TU; XIANGYONG YANG; XINZHOU DENG; MENG XIONG; JIE XIONG; QIUPING ZHANG
- Abstract
Tripartite motif containing 28 (TRIM28) is a transcriptional regulator acting as an essential corepressor for Krüppel-associated box zinc finger domain-containing proteins in multiple tissue and cell types. An increasing number of studies have investigated the function of TRIM28; however, its prognostic value in breast cancer (BC) remains unclear. In the present study, the expression of TRIM28 was identified to be significantly higher in cancerous compared with healthy tissue samples. Furthermore, it was demonstrated that TRIM28 expression was significantly correlated with several clinicopathological characteristics of patients with BC, such as p53 mutation, tumor recurrence and Elston grade of the tumor. In addition, a protein-protein interaction network was created to illustrate the interactions of TRIM28 with other proteins. The prognostic value of TRIM28 in patients with BC was investigated using the Kaplan-Meier Plotter database, which revealed that high expression of TRIM28 is a predictor of poor prognosis in patients with BC. In conclusion, the results of the present study indicate that TRIM28 provides a survival advantage to patients with BC and is a novel prognostic biomarker, in addition to being a therapeutic target for the treatment of BC.
- Subjects
BREAST cancer treatment; ZINC-finger proteins; BIOINFORMATICS; KAPLAN-Meier estimator; KRUPPEL-like factors
- Publication
Oncology Letters, 2017, Vol 13, Issue 4, p2670
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2017.5764