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- Title
The Effects of Long-Term Chaetomellic Acid A Administration on Renal Function and Oxidative Stress in a Rat Model of Renal Mass Reduction.
- Authors
Nogueira, António; Peixoto, Francisco; Oliveira, Maria Manuel; Pires, Carlos André; Colaço, Bruno; Oliveira, Paula Alexandra; Pires, Maria João
- Abstract
Purpose. This study aimed to evaluate the effect of chronic treatment with chaetomellic acid A (CAA) on oxidative stress and renal function in a model of renal mass reduction. Methods. Male Wistar rats were subjected to 5/6 nephrectomy (RMR) or sham-operated (SO). One week after surgery, rats have been divided into four experimental groups: RMR: RMR rats without treatment (n=14); RMR + CAA: RMR rats treated with CAA (n=13); SO: SO rats without treatment (n=13); and SO + CAA: SO rats treated with CAA (n=13). CAA was intraperitoneally administered in a dose of 0.23 µg/Kg three times a week for six months. Results. RMR was accompanied by a significant reduction in catalase and glutathione reductase (GR) activity (p<0.05) and a decrease in reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio. CAA administration significantly increased catalase and GR activity (p<0.05) and increased GSH/GSSG ratio, but no significant difference between the treated and nontreated groups was found in this ratio. No significant differences were found between the RMR groups in any of the parameters of renal function. However, CAA administration slightly improves some parameters of renal function. Conclusions. These data suggest that CAA could attenuate 5/6 RMR-induced oxidative stress.
- Subjects
UNITED States; KIDNEY physiology; CHRONIC kidney failure complications; ANALYSIS of variance; ANIMAL experimentation; BLOOD pressure; BLOOD pressure measurement; BODY weight; CHRONIC kidney failure; GLUTATHIONE; HEART rate monitoring; HEMATOCRIT; INFLAMMATION; KIDNEYS; LICHENS; LIVER; MEDICAL care costs; OXIDATION-reduction reaction; PUBLIC health; RATS; RESEARCH funding; STATISTICS; SURVIVAL; URINARY organ physiology; DATA analysis; OXIDATIVE stress; DICARBOXYLIC acids; NEPHRECTOMY; DESCRIPTIVE statistics; KRUSKAL-Wallis Test
- Publication
BioMed Research International, 2017, Vol 2017, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2017/5125980