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- Title
Changes in gut hormones and leptin in military personnel during operational deployment in Afghanistan.
- Authors
Hill, Neil E.; Fallowfield, Joanne L.; Delves, Simon K.; Ardley, Christian; Stacey, Michael; Ghatei, Mohammad; Bloom, Stephen R.; Frost, Gary; Brett, Stephen J.; Wilson, Duncan R.; Murphy, Kevin G.
- Abstract
Objective Understanding the mechanisms that drive weight loss in a lean population may elucidate systems that regulate normal energy homeostasis. This prospective study of British military volunteers investigated the effects of a 6-month deployment to Afghanistan on energy balance and circulating concentrations of specific appetite-regulating hormones. Methods Measurements were obtained twice in the UK (during the Pre-deployment period) and once in Afghanistan, at Mid-deployment. Body mass, body composition, food intake, and appetite-regulatory hormones (leptin, active and total ghrelin, PYY, PP, GLP-1) were measured. Results Repeated measures analysis of 105 volunteers showed body mass decreased by 4.9% ± 3.7% ( P < 0.0001) during the first half of the deployment. Leptin concentrations were significantly correlated with percentage body fat at each time point. The reduction in percentage body fat between Pre-deployment and Mid-deployment was 8.6%, with a corresponding 48% decrease in mean circulating leptin. Pre-deployment leptin and total and active ghrelin levels correlated with subsequent change in body mass; however. no changes were observed in the anorectic gut hormones GLP-1, PP, or PYY. Conclusions These data suggest that changes in appetite-regulating hormones in front line military personnel occur in response to, but do not drive, reductions in body mass.
- Subjects
LEPTIN; INTESTINAL hormones; GASTROINTESTINAL hormones; HEALTH of military personnel; DEPLOYMENT (Military strategy); VOLUNTARY military service; AFGHAN War, 2001-2021
- Publication
Obesity (19307381), 2015, Vol 23, Issue 3, p608
- ISSN
1930-7381
- Publication type
Article
- DOI
10.1002/oby.21000