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- Title
Determination of triterpenoids from birch bark by liquid chromatography-tandem mass spectrometry.
- Authors
Kosyakov, D.; Ul'yanovskii, N.; Falev, D.
- Abstract
Pentacyclic triterpenoids from birch bark are of great interest as biologically active substances and raw materials for producing a wide range of drugs. In this work, a method for the highly sensitive determination of betulin, betulinic acid, lupeol, and erythrodiol in plant extracts based on a combination of high-performance liquid chromatography with tandem mass spectrometric detection is proposed. Mass spectra under the conditions of atmospheric pressure chemical ionization and collision-induced dissociation spectra of analytes are obtained. The conditions for mass spectrometric detection in the multiple reaction monitoring mode are optimized. The calculated detection limits are in the range 0.7-1.8 μg/L.
- Subjects
TRITERPENOIDS; BIRCH bark extract; BETULIN; LIQUID chromatography-mass spectrometry; PLANT metabolites
- Publication
Journal of Analytical Chemistry, 2014, Vol 69, Issue 13, p1264
- ISSN
1061-9348
- Publication type
Article
- DOI
10.1134/S1061934814130061