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- Title
Integrative molecular profiling identifies two molecularly and clinically distinct subtypes of blastic plasmacytoid dendritic cell neoplasm.
- Authors
Künstner, Axel; Schwarting, Julian; Witte, Hanno M.; Bernard, Veronica; Stölting, Stephanie; Kusch, Kathrin; Nagarathinam, Kumar; von Bubnoff, Nikolas; Murga Penas, Eva Maria; Merz, Hartmut; Busch, Hauke; Feller, Alfred C.; Gebauer, Niklas
- Abstract
Thirdly, deconvolution of our bulk gene expression profiles using single-cell transcriptome data predicted abundances of cell types within the mixed cell population of our BPDCN biopsies, independent of localization or tumor cell content/purity. Link width correlates with the number of reads supporting the fusion event; G location of SCNAs along the genome and gistic G-scores (G = Frequency × Amplitude; red bars denote gains and blue bars losses; gene names refer to affected oncogenes and tumor-suppressor genes within identified regions). The genes within these SCNAs recurrently led to the loss of tumor-suppressor genes (TSGs; I CDKN2A i , I NOTCH1 i , I RB1 i , and I BRCA2 i ) and copy number gains in oncogenes ( I IDH2 i , I U2AF1 i , I MET i , and I EZH2 i ) (Fig.
- Subjects
DENDRITIC cells; TUMORS
- Publication
Blood Cancer Journal, 2022, Vol 12, Issue 7, p1
- ISSN
2044-5385
- Publication type
Article
- DOI
10.1038/s41408-022-00699-1