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- Title
Immunohistochemical analysis of the outer plexiform layer in the nob mouse shows no abnormalities.
- Authors
SHERRY L. BALL; MACHELLE T. PARDUE; MAUREEN A. MCCALL; RONALD G. GREGG; NEAL S. PEACHEY
- Abstract
In the nob mouse, a mutation in nyctalopin results in a loss of signal transmission from photoreceptors to depolarizing bipolar cells (DBCs). We used immunohistochemical techniques to assess the expression pattern of proteins found at either the photoreceptor terminal or bipolar cell dendrites within the outer plexiform layer. We labeled normal and nob retinas with antibodies against mGluR6, PKC, G0α, bassoon, PSD-95, the α1F subunit of voltage-gated calcium channels, trkB, and dystrophin. All labeling patterns in nob and normal retinas were comparable to those previously reported in mouse retina. Our results indicate that the absence of nyctalopin does not disrupt the expression pattern of other proteins known to be required for synaptic transmission.
- Subjects
MICE; GENETIC mutation; PHOTORECEPTORS; PROTEINS; CALCIUM channels
- Publication
Visual Neuroscience, 2003, Vol 20, Issue 3, p267
- ISSN
0952-5238
- Publication type
Article
- DOI
10.1017/s0952523803203059