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- Title
Function of p21 and its therapeutic effects in esophageal cancer (Review).
- Authors
LEI WANG; HUIQIONG HAN; LIN DONG; ZEHUA WANG; YANRU QIN
- Abstract
Esophageal cancer (EC) is the eighth most common type of cancer worldwide and ranks sixth among the causes of cancer-related mortality. Due to the high mortality rate and poor treatment efficacy for EC, millions of individuals succumb to this disease; thus, the identification of novel treatment targets is of utmost importance and urgency. In recent years, there have been advances if therapies targeting cell cycle regulators. p21 is a type of cell cycle regulator that plays a dual role in tumor cells, as it can not only regulate the cell cycle, induce apoptosis and inhibit cell proliferation, but can also protect cells from apoptosis. It has been found that p21 often exerts a tumor-suppressive effect on EC, which provides a basis for its use as a treatment target for EC. Therefore, the aim of the present study was to review the function of p21 and its potential value as a therapeutic target for EC.
- Subjects
TREATMENT effectiveness; CELL cycle; CANCER-related mortality; CELL proliferation; POTENTIAL functions; ESOPHAGEAL cancer
- Publication
Oncology Letters, 2021, Vol 21, Issue 2, p1
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2020.12397