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- Title
Hepatocellular carcinoma stem cell-like cells are enriched following low-dose 5-fluorouracil chemotherapy.
- Authors
YONGQIANG ZHAN; LISHA MOU; KANGWEN CHENG; CHENGYOU WANG; XUESONG DENG; JUNREN CHEN; ZHIBING FAN; YONG NI
- Abstract
It has been proposed that cancer stem cells (CSCs) are involved in tumor resistance to chemotherapy and tumor relapse. The goal of the present study was to determine the effect of low-dose 5-fluorouracil (5-Fu) on enriched hepatocellular CSC-like cells. Increased cell motility and epithelial-mesenchymal transition were observed by migration assay in human hepatoblastoma PLC/RAF/5 cells following 5-Fu treatment, as well as a significant enhancement in their sphere-forming abilities. CSC-like cells were identified by side population cell analysis. The percentage of CSC-like cells in the surviving cells was greatly increased in response to 5-Fu. These findings indicate that low-dose 5-Fu treatment may efficiently enrich the CSC-like cell population in PLC/RAF/5 cells.
- Subjects
FLUOROURACIL; CANCER chemotherapy; LIVER cancer; STEM cells; CELL populations
- Publication
Oncology Letters, 2016, Vol 12, Issue 4, p2511
- ISSN
1792-1074
- Publication type
Article
- DOI
10.3892/ol.2016.4975