We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Immunoreactivity of cAMP response element binding protein is not altered in the post-mortem cerebral cortex or cerebellum of alcoholics.
- Authors
Yamamoto, Megumi; Pohli, Sabine; Durany, Nuria; Ozawa, Hiroki; Saito, Toshikazu; Boissl, Karl W.; Zöchling, Robert; Riederer, Peter; Böning, Jobst; Götz, Mario E.
- Abstract
— We examined amounts of cAMP response element binding protein (CREB) and its phosphorylated form in post-mortem frontal and temporal cortices and cerebella from alcoholics and controls by immunoblotting. No significant differences were observed in the levels of these proteins in each brain region, suggesting that the assumed neuroadaptations to chronic ethanol intake may not be reflected by quantitative alterations of CREB in alcoholic brain.
- Subjects
PHYSIOLOGICAL effects of alcohol; EFFECT of drugs on the brain; ALCOHOL drinking; ALCOHOLISM treatment; BRAIN physiology; CEREBRAL cortex; CEREBELLUM; DIAGNOSTIC immunoblotting; PHYSIOLOGY
- Publication
Alcohol & Alcoholism, 2001, Vol 36, Issue 1, p70
- ISSN
0735-0414
- Publication type
Article
- DOI
10.1093/alcalc/36.1.70