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- Title
The immune checkpoints storm in COVID‐19: Role as severity markers at emergency department admission.
- Authors
Avendaño‐Ortiz, José; Lozano‐Rodríguez, Roberto; Martín‐Quirós, Alejandro; Terrón, Verónica; Maroun‐Eid, Charbel; Montalbán‐Hernández, Karla; Valentín‐Quiroga, Jaime; García‐Garrido, Miguel Ángel; del Val, Elena Muñoz; del Balzo‐Castillo, Álvaro; Peinado, María; Gómez, Laura; Herrero‐Benito, Carmen; Rubio, Carolina; Casalvilla‐Dueñas, José Carlos; Gómez‐Campelo, Paloma; Pascual‐Iglesias, Alejandro; del Fresno, Carlos; Aguirre, Luis A.; López‐Collazo, Eduardo
- Abstract
SCD25, sTim-3 and Galectin-9 showed to be increased in patients versus HV despite the fact that they developed mild disease (Figure 1C-E). We found sCD25, sTim-3, Galectin-9, sPD-L1 and sCD86 exhibited differences between groups (Figure 1C-L). In addition, sCD25, sTim-3, Galectin-9, sPD-L1 and sPD-1 showed increased levels in severe patients and/or exitus compared with mild ones (Figure 1C-G). GLO:F2H7/01oct21:ctm2573-fig-0001.jpg PHOTO (COLOR): 1 Distribution of patients and plasma immune checkpoint levels according to outcome of patients with COVID-19 on admission, compared with HVs.
- Subjects
IMMUNE checkpoint proteins; COVID-19; HOSPITAL emergency services; COVID-19 pandemic; MEDICAL personnel; CARDIOVASCULAR diseases
- Publication
Clinical & Translational Medicine, 2021, Vol 11, Issue 10, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.573