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- Title
A mutational signature for colorectal cancer prognosis prediction: Associated with immune cell infiltration.
- Authors
Xu, Liang; Lin, Yanyun; Chen, Xijie; Zheng, Lisheng; Cheng, Yufeng; Hu, Jiancong; Zheng, Bin; Zhang, Bin; Li, Guanman; Chi, Zengjie; Guo, Shuang; Liu, Danling; He, Xiaosheng; Lan, Ping
- Abstract
GLO:F2H7/01may21:ctm2414-fig-0002.jpg PHOTO (COLOR): 2 Mutational landscape of significantly mutated genes in the training cohort and verification cohort. The data showed that more than 90% of CRC in the low-risk group had more mutations in the MSKCC cohort (Figure 2B), which means most of the genes with more mutations in the low-risk group. Dear Editor, Colorectal cancer (CRC) is considered as a genetic disease, which arises from the stepwise accumulation of genetic and epigenetic alterations.1,2 We found a novel mutational signature (MS) that could assist clinicians to select patients who are more suitable for immunotherapy; the risk score (RS) combined with pathological TNM stage could provide comprehensive and precise prognostic information for CRC patients. Moreover, the MS classifier can be used to predict patients who are more suitable for immunotherapy, and a nomogram comprising the MS could help medical staff in directing personalized therapeutic treatment selection for CRC patients.
- Subjects
COLORECTAL cancer; NOMOGRAPHY (Mathematics); CANCER prognosis; ADENOMATOUS polyposis coli; PROGRAMMED cell death 1 receptors
- Publication
Clinical & Translational Medicine, 2021, Vol 11, Issue 5, p1
- ISSN
2001-1326
- Publication type
Article
- DOI
10.1002/ctm2.414