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- Title
DIFFERENCES IN THE SENSITIZING CAPACITY OF NEOMYCIN IN CREAMS AND IN OINTMENTS.
- Authors
Hjorth, Niels; Thomsen, Kristian
- Abstract
In 1963-4,10% of patients with dermatitis gave positive patch test reactions to neomycin. Of 115 patients 89(77%) had used neomycin in ointment bases, while only 14 (12%) had used creams or lotions, and 7 (6%) powders. In order to establish the extent to which different preparations were pres cribed a market analysis was performed. The sale in 1964 of neomycin for topical use was found to be 137,000 units (tubes or other containers). A small number of proprietary preparations dominated the market. In proportion to their sale creams, lotions and powders containing neomycin were rarely connected with sensitization. This investigation suggests that neomycin ointments are the major cause of sensitization to this antibiotic. The possible significance of these findings and the influence of the vehicle on sensitizing capacity are discussed. It is recommended that neomycin should not be prescribed in ointments. The risk of inducing sensitization with neomycin in creams, lotions or powders appears to be significantly less.
- Subjects
NEOMYCIN; SKIN inflammation; OINTMENTS; AMINOGLYCOSIDES; COSMETICS; TUBES
- Publication
British Journal of Dermatology, 1968, Vol 80, Issue 3, p163
- ISSN
0007-0963
- Publication type
Article
- DOI
10.1111/j.1365-2133.1968.tb12287.x