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- Title
Synthesis of c-di-GMP analogs modified by ganciclovir and biological activity to induce type I interferon.
- Authors
Hong Dai; Xiaotong Yu; Zhu Guan; Lihe Zhang; Zhenjun Yang
- Abstract
C-di-GMP is one kind of second messengers which plays an important role not only in the regulation of various bacterial physiological activities but also in the activation of innate immune response to induce type I interferon in mammalian cells. In this assay, by using one-pot phosphoramidite method, three novel kinds of analogs of c-di-GMP including its phosphorthiates modified by ganciclovir (7a, 7b, 7c) have been designed and synthesized. The immune-stimulatory results of these c-di-GMP analogs in RAW-Lucia ISG cells indicated that they couldn't induce the release of type I interferon, which demonstrated that the intact structure of ribose moieties is very vital for their bioactivity upon the activation of STING signaling pathway.
- Subjects
TYPE I interferons; IMMUNE response
- Publication
Journal of Chinese Pharmaceutical Sciences, 2019, Vol 28, Issue 12, p825
- ISSN
1003-1057
- Publication type
Article
- DOI
10.5246/jcps.2019.12.078