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- Title
Topical formulations containing Copaifera duckei Dwyer oleoresin improve cutaneous wound healing.
- Authors
Gonçalves Dias, Fernanda Gosuen; Freitas Pereira, Lucas de; Furtado, Ricardo Andrade; Magalhães, Geórgia Modé; Miguel, Marina Pacheco; Gosuen Gonçalves Dias, Luis Gustavo; Jorge, Adriana Torrecilhas; Santos Honsho, Cristiane dos; Ambrósio, Sérgio Ricardo; Bastos, Jairo Kenupp; Carrijo, Micaela Silva; Tavares, Denise Crispim
- Abstract
Objective: Evaluation of the healing and toxicological effects of Copaifera duckei Dwyer oleoresin (CDO). Materials and Methods: Rodents with skin lesions were divided into nine groups, including daily treatments with 1, 3 and 10% CDO, collagenase, antibiotic ointment and control groups, for 14 days. Results: Treatment with 10% CDO reduced skin edema and hyperplasia, demonstrating anti-inflammatory effect of the oil. Reduction in the wound area was observed, indicating the healing effect of CDO. Histopathological analysis showed increases in angiogenesis and re-epithelialization in animals treated with the highest concentration. On the other hand, no alterations in ulcerations, inflammatory infiltrate, hemorrhage, congestion, degeneration, percentage of collagen fibers, number of cells stained with antimacrophage migration inhibitory factor, or density of area stained with anti-collagen I and III were found. Toxicogenetic analysis revealed no differences in micronucleus frequencies or in the ratio of polychromatic erythrocytes to total erythrocytes between treated and negative control, demonstrating the absence of genotoxicity and cytotoxicity, respectively. There was no difference in levels of liver enzymes among groups, indicating the absence of hepatotoxicity. Conclusion: Formulations of CDO exerted beneficial effects on the stages of cutaneous wound healing and are promising options for the treatment of wounds.
- Subjects
SKIN injuries; WOUND healing; LIVER enzymes; HEALING; ERYTHROCYTES; NEOVASCULARIZATION
- Publication
Avicenna Journal of Phytomedicine, 2021, Vol 11, Issue 2, p120
- ISSN
2228-7930
- Publication type
Article