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- Title
Dietary approaches to stop hypertension (DASH) diet improves hepatic fibrosis, steatosis and liver enzymes in patients with non-alcoholic fatty liver disease: a randomized controlled trial.
- Authors
Sangouni, Abbas Ali; Nadjarzadeh, Azadeh; Rohani, Fatemeh Sadat; Sharuni, Fatemeh; Zare, Zahra; Rahimpour, Shahab; Hojjat, Hashem; Hosseinzadeh, Mahdieh
- Abstract
Purpose: Recent evidence suggests that adherence to dietary approaches to stop hypertension (DASH) diet can be effective in managing non-alcoholic fatty liver disease (NAFLD). We investigated the effect of DASH diet on hepatic fibrosis, steatosis and liver enzymes in patients with NAFLD. Methods: This 12-week randomized controlled trial was conducted among seventy patients with NAFLD who were randomly assigned into two groups including intervention group (DASH diet containing 50–55% carbohydrate, 15–20% protein, and 30% total fat) and the control group (a healthy diet containing 50–55% carbohydrate, 15–20% protein, and 30% total fat). Both diets were calorie-restricted (500–700 kcal lower than the energy requirement). The primary outcomes included hepatic fibrosis, hepatic steatosis, alanine transaminase (ALT), aspartate transaminase (AST) and gamma-glutamyl transpeptidase (GGT). Results: At the baseline, there was no significant difference between two groups in the level of hepatic fibrosis (P = 0.63), hepatic steatosis (P = 0.53), ALT (P = 0.93), AST (P = 0.18) and GGT (P = 0.76). A significant reduction was found in the intervention group compared to the control group in hepatic fibrosis (23 grades reduction vs. 7 grades reduction; P = 0.008) and hepatic steatosis (31 grades reduction vs. 9 grades reduction; P = 0.03) after intervention. In addition, a significant change was observed in the intervention group compared to control group in ALT (– 8.50 ± 8.98 vs. – 2.09 ± 7.29; P = 0.002), and AST (– 5.79 ± 6.83 vs. – 0.51 ± 6.62; P = 0.002). Conclusions: Adherence to DASH diet may be effective in management of NAFLD. Trial registration: The trial was registered on 06 February 2022 at Iranian Registry of Clinical Trials (IRCT20170117032026N3) with URL: https://www.irct.ir/trial/60887.
- Subjects
IRAN; GAMMA-glutamyltransferase; REPORTING of diseases; SALT-free diet; FATTY liver; NON-alcoholic fatty liver disease; CIRRHOSIS of the liver; DIET; TREATMENT effectiveness; RANDOMIZED controlled trials; COMPARATIVE studies; DASH diet; ENZYMES; RESEARCH funding; HEALTH behavior; CARBOHYDRATES; DESCRIPTIVE statistics; STATISTICAL sampling; ALANINE aminotransferase; ASPARTATE aminotransferase
- Publication
European Journal of Nutrition, 2024, Vol 63, Issue 1, p95
- ISSN
1436-6207
- Publication type
Article
- DOI
10.1007/s00394-023-03221-w