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- Title
As a matter of fat: Emerging roles of lipid‐sensitive E3 ubiquitin ligases.
- Authors
Gawden‐Bone, Christian M.; Lehner, Paul J.; Volkmar, Norbert
- Abstract
The dynamic structure and composition of lipid membranes need to be tightly regulated to control the vast array of cellular processes from cell and organelle morphology to protein‐protein interactions and signal transduction pathways. To maintain membrane integrity, sense‐and‐response systems monitor and adjust membrane lipid composition to the ever‐changing cellular environment, but only a relatively small number of control systems have been described. Here, we explore the emerging role of the ubiquitin‐proteasome system in monitoring and maintaining membrane lipid composition. We focus on the ER‐resident RNF145 E3 ubiquitin ligase, its role in regulating adiponectin receptor 2 (ADIPOR2), its lipid hydrolase substrate, and the broader implications for understanding the homeostatic processes that fine‐tune cellular membrane composition.
- Subjects
UBIQUITIN ligases; MEMBRANE lipids; FAT; PROTEIN-protein interactions; CELL morphology; ARRAY processing
- Publication
BioEssays, 2023, Vol 45, Issue 12, p1
- ISSN
0265-9247
- Publication type
Article
- DOI
10.1002/bies.202300139