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- Title
BIOANALYTICAL METHOD PROCESS OF CHROMATOGRAPHIC ANALYSIS OF TIZANIDINE IN THE FORMULATION AND HUMAN PLASMA.
- Authors
Venkatesh, D. Nagasamy; Shanmugakumar, S. D.; Najam, Asfia; Parameshwar, Pabba; Mahendar, K.; Divya, Bodige; Narsingam, E.
- Abstract
An optimized, simple, accurate method is developed to quantify Tizanidine in bulk and pharmaceutical formulation using the RP - HPLC method using a silica ODS C18 column with the aid of MeOH: H2O:0.01M orthophosphoric acid (95:4:1 v/v/v) as a mobile phase and deduced at 320nm. The RT value was found to be 2.274 with a resolution of 1.167 respectively. The spiking studies of Tizanidine in human plasma were also carried out. The linearity studies of TZA (10 -50 mcg/mL) were found to be R2 =0.99979 (API) and R2 = 0.8155 respectively. The suggested study was validated as per the criteria of the ICH guidelines. The proposed study could be easily adopted in the pharmaceutical industry for performing quantitative analyses.
- Subjects
CHROMATOGRAPHIC analysis; HIGH performance liquid chromatography; PHARMACEUTICAL industry; QUANTITATIVE research
- Publication
Rasayan Journal of Chemistry, 2023, Vol 16, Issue 1, p422
- ISSN
0974-1496
- Publication type
Article
- DOI
10.31788/RJC.2023.1618127