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- Title
SYNTHESIS OF SILVER NANOPARTICLES USING ETHANOLIC EXTRACT OF Nelumbo nucifera Gaertn. LEAF AND ITS CYTOTOXIC ACTIVITY AGAINST T47D AND 4T1 CELL LINES.
- Authors
Fitri, K.; Andry, M.; Khairani, T. N.; Winata, H. S.; Violenta, A.; Lubis, N.; Lubis, M. F.
- Abstract
The cytotoxic activitiy of silver nanoparticles bio-functionalized by Nelumbo nucifera leaf extracts were examined in the current work. The nanoparticle (AgNPs) was characterized by scanning electron microscopy, UV-visible spectroscopy, and a particle size analyzer. Cytotoxic activity of silver nanoparticles against T47D and 4T1 cells using the MTT method using concentrations of 100 μg/mL, 50 μg/mL, and 25 μg/mL. For comparison, doxorubicin was used at the same dose. The size of the spherical nanoparticle was 66.4±0.93 nm and the polydispersity index was 0.23±0.05. Silver nanoparticles have anti-cancer properties against T47D and 4T1 cell lines based on inhibitory concentration. The inhibitory concentration (IC50) of AgNPs on T47D and 4T1 cells were obtained at 12.10±0.08 μg/mL and 98.77±1.27 μg/mL, respectively. Meanwhile, the IC50 values of doxorubicin in T47D and 4T1 cells were 4.45±0.03 μg/mL and 36.77±1.15 μg/mL, respectively. Overall, the results revealed that the green-synthetized silver nanoparticle had cytotoxic effects on breast cancer cells in comparison to doxorubicin.
- Subjects
SILVER nanoparticles; CELL lines; EAST Indian lotus; NANOPARTICLES; NANOPARTICLE size; ULTRAVIOLET-visible spectroscopy
- Publication
Rasayan Journal of Chemistry, 2023, Vol 16, Issue 1, p104
- ISSN
0974-1496
- Publication type
Article
- DOI
10.31788/RJC.2023.1618000