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- Title
SQUID PENS MEDIATED SILVER NANOPARTICLES SYNTHESIS, ITS CHARACTERISATION, AND BIOLOGICAL ACTIVITIES.
- Authors
Ragunathan, Venkataraghavan; Sudharsan, Meenambiga Setti; S. R., Roshini; Sundar, Gomathy; K., Chithra
- Abstract
This research scintillates the synthesis of silver nanoparticles from chitosan (C-AgNps) from squid pens as a reducing and stabilizing agent and assesses its antioxidant, antibacterial, and anticancer potentials. The nanoparticles were 240 to 290 nm with excellent stability of +98.2 mV. The C-AgNps possessed an excellent 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity with an IC50 of 6.65 μg/mL. The C-AgNps showed exceptional antibacterial properties against S. aureus, B. subtilis, P. aeruginosa, and E. coli using a good diffusion assay. The C-AgNps also showed outstanding anticancer properties against A375 human skin malignant melanoma. Thus, the C-AgNps could be used as antimicrobial and anticancer agents for novel therapeutics after lead optimization and in-vivo clinical trials.
- Subjects
ESCHERICHIA coli; SQUIDS; NANOPARTICLES analysis; STABILIZING agents; MELANOMA; SILVER nanoparticles; REDUCING agents; NANOPARTICLE synthesis
- Publication
Rasayan Journal of Chemistry, 2023, Vol 16, Issue 1, p24
- ISSN
0974-1496
- Publication type
Article
- DOI
10.31788/RJC.2023.1618129