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- Title
Total Synthesis of (±)-Integrifolin.
- Authors
Katsuya Shimomaki; Hiroyuki Kusama; Iwasawa, Nobuharu
- Abstract
The total synthesis of (±)-integrifolin has been achieved for the first time through the stereoselective preparation of the bicyclo[5.3.0]decane skeleton based on the tungsten-catalyzed cyclization of acyclic trienynes under photoirradiation conditions. Further key transformations of the cyclized product are the Tamao oxidation through cyclic silyl ether, the introduction of two oxygen functionalities by the oxidation of the diene and the construction of three exo-methylene moieties.
- Subjects
STEREOSELECTIVE reactions; BICYCLODECENES; TUNGSTEN; IRRADIATION; SILYL ethers; OXIDATION
- Publication
Chemistry - An Asian Journal, 2016, Vol 6, p9953
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/chem.201601275