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- Title
Pot, atom and step-economic (PASE) synthesis of medicinally relevant spiro[oxindole-3,4′-pyrano[4,3- b]pyran] scaffold.
- Authors
Elinson, Michail N.; Ryzhkov, Fedor V.; Korolev, Victor A.; Egorov, Mikhail P.
- Abstract
Fast (3 min) pot, atom and step economics (PASE) potassium fluoride catalyzed multicomponent reaction of isatins, malononitrile and 4-hydroxy-6-methyl-2 H-pyran-2-one results in efficient formation of substituted spirooxindole-3,4′-pyrano[4,3- b]pyrans in 92-96% yields. The developed 'on-solvent' approach to the substituted spirooxindole-3,4′-pyrano[4,3- b]pyrans - the pharmacologically perspective substances with known antiviral, antileishmanial, anticonvulsant and anti-HIV activities - is beneficial from the viewpoint of diversity-oriented large-scale processes and represents fast and environmentally benign synthetic concept for the multicomponent reactions strategy.
- Subjects
POTASSIUM fluoride; ISATIN; MALONONITRILE; PYRAN synthesis; CHEMICAL synthesis
- Publication
Heterocyclic Communications, 2016, Vol 22, Issue 1, p11
- ISSN
0793-0283
- Publication type
Article
- DOI
10.1515/hc-2015-0232