We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Long-Term Pulmonary Damage in Surviving Antitoxin-Treated Mice following a Lethal Ricin Intoxication.
- Authors
Gal, Yoav; Sapoznikov, Anita; Lazar, Shlomi; Shoseyov, David; Aftalion, Moshe; Gutman, Hila; Evgy, Yentl; Gez, Rellie; Nevo, Reinat; Falach, Reut
- Abstract
Ricin, a highly potent plant-derived toxin, is considered a potential bioterrorism weapon due to its pronounced toxicity, high availability, and ease of preparation. Acute damage following pulmonary ricinosis is characterized by local cytokine storm, massive neutrophil infiltration, and edema formation, resulting in respiratory insufficiency and death. A designated equine polyclonal antibody-based (antitoxin) treatment was developed in our laboratory and proved efficacious in alleviating lung injury and increasing survival rates. Although short-term pathogenesis was thoroughly characterized in antitoxin-treated mice, the long-term damage in surviving mice was never determined. In this study, long-term consequences of ricin intoxication were evaluated 30 days post-exposure in mice that survived antitoxin treatment. Significant pulmonary sequelae were demonstrated in surviving antitoxin-treated mice, as reflected by prominent histopathological changes, moderate fibrosis, increased lung hyperpermeability, and decreased lung compliance. The presented data highlight, for the first time to our knowledge, the possibility of long-term damage development in mice that survived lethal-dose pulmonary exposure to ricin due to antitoxin treatment.
- Subjects
RICIN; LUNGS; MICE; CYTOKINE release syndrome; RESPIRATORY insufficiency; ANTITOXINS; SURVIVAL rate
- Publication
Toxins, 2024, Vol 16, Issue 2, p103
- ISSN
2072-6651
- Publication type
Article
- DOI
10.3390/toxins16020103