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- Title
Comparison of Perceived Itch Induced by Skin Prick-tests with Histamine and Codeine.
- Authors
Theunis, Jennifer; Black, David; Degouy, Arnaud; Schmitt, Anne-Marie; Misery, Laurent
- Abstract
The role of personal factors makes it difficult to correlate subjective data, such as those obtained with the use of a visual analogue scale, and objective data, such as a quantity of injected histamine. In this study, prick tests with histamine and codeine on the forearms allowed a coherent variation in itch scores to be obtained over time, with highly significant differences from controls and with a peak at 4 minutes. These tests are therefore valuable for screening anti-pruritic agents. A significant difference between initial scores and scores for new prick tests after 7 days suggest that tachyphylaxis persists.
- Subjects
HISTAMINE; CODEINE; TACHYPHYLAXIS; DRUG tolerance; INFLAMMATORY mediators
- Publication
Acta Dermato-Venereologica, 2008, Vol 88, Issue 5, p455
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-0482