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- Title
Crescentic glomerulonephritis associated with syphilis: a case report and review of the literature.
- Authors
Kaiga, Akiko; Sato, Yuka; Arakawa, Haruna; Rai, Tatemitsu; Tojo, Akihiro
- Abstract
Background: Crescentic glomerulonephritis with syphilis infection is rare, and the mechanism underlying the formation of glomerular capillary wall damage-induced crescent has not been elucidated. Case presentation: A 62-year-old Japanese male showed edema, eruption, and rapid deterioration of the renal function after an acute syphilis infection. A renal biopsy showed crescentic glomerulonephritis with C3 deposition in the glomerular capillary wall, and immunostaining for anti-Treponema pallidum antibody was weakly positive in some interstitium and one glomerulus. Electron microscopy revealed the presence of string-shaped structures in the glomerular capillary walls. After treatment with penicillin followed by prednisolone, the renal function and urinary abnormalities, including Treponema pallidum protein, disappeared. Conclusions: Crescentic glomerulonephritis associated with syphilis showed a string-shaped deposition in the glomerular capillary and urinary Treponema pallidum protein excretion, and was effectively treated with penicillin and prednisolone.
- Subjects
LITERATURE reviews; SYPHILIS; GLOMERULONEPHRITIS; TREPONEMA pallidum; RENAL biopsy; KIDNEY physiology
- Publication
Journal of Medical Case Reports, 2023, p1
- ISSN
1752-1947
- Publication type
Case Study
- DOI
10.1186/s13256-023-04293-2