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- Title
Arterial stiffness in moderate-severe obstructive sleep apnea.
- Authors
Zota, Ioana Madalina; Sascau, Radu; Statescu, Cristian; Roca, Mihai; Boisteanu, Daniela; Leon Constantin, Maria Magdalena; Mastaleru, Alexandra; Vasilcu, Teodor; Gavril, Radu; Mitu, Florin
- Abstract
Objectives – Obstructive sleep apnea (OSA) has been linked to arterial stiffness and increased cardiovascular risk. The aim of this study was to analyse the relationship between OSA severity, arterial stiffness and clinico-biological parameters in moderate-severe OSA subjects. Methods – We assessed arterial stiffness using the Arteriograph (Tensiomed, Hungary) in 41 patients with newly diagnosed moderate-severe OSA prior to the initiation of positive pressure therapy. Results – Our study included 18 and 23 patients with moderate and severe OSA, respectively. Mean apnea hypopnea index (AHI) 40.69 events/h. Desaturation index, minimum nocturnal O2 saturation, erythrocyte sedimentation rate (ESR), ejection duration and return time were significantly different between the two subgroups. AHI was correlated with the other OSA severity parameters but also with pulse wave velocity (PWV), C reactive protein and ESR. PWV was negatively correlated with magnesium. Mean nocturnal oxygen saturation, age, body mass index and abdominal circumference did not significantly differ between the moderate and severe OSA subgroups. Conclusions – PWV and inflammation markers are correlated with OSA severity. We also found a negative correlation between serum magnesium and PWV in moderate-severe OSA patients.
- Subjects
GAUTENG (South Africa); ARTERIAL diseases; SLEEP apnea syndromes; BLOOD sedimentation; BODY mass index; DISSOLVED oxygen in water
- Publication
Romanian Journal of Cardiology, 2019, Vol 29, Issue 1, p27
- ISSN
1220-658X
- Publication type
Article