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- Title
Normal range glycated hemoglobin A1c is associated with reduced pulmonary function in middle-aged adults.
- Authors
SILVA, FERNANDA M.; FERREIRA, JOSÉ P.; TEIXEIRA, ANA M.; SOARES, CARLOS M.; RODRIGUES, RAFAEL N.; FARINHA, CARLOS; DUARTE-MENDES, PEDRO
- Abstract
Glycated haemoglobin (HbA1c) has been related to impaired lung function in the diabetic population. Few studies have analysed the association between lung function and HbA1c in the non-diabetic population. We investigated whether HbA1c below the diagnostic threshold is associated with lung function parameters. Forty non-diabetic adults took part in this study. Fasting blood samples were drawn to determine the HbA1c level. Lung function was assessed by spirometry using the Spiropalm 6MWT (Cosmed, Italy) Spirometer. One-way ANOVA was performed to detect significant differences between the groups according to their HbA1c level (%). Pearson and Spearman's correlations were used to determine the associations between variables. Participants were divided into 3 groups according to HbA1c level as follows: Group 1 (n = 18), = 5.0 to = 5.5%; Group II (n = 10), >5.5 and = 5.7%; and Group III (n = 12), >5.7 and = 6.2%.Group I had the higher FVC (108.33 ± 13.81% pred.), FEV1 (108.11 ± 14.92% pred.), PFE (7.63 ± 2.25 L/s) and the lowest FEV1/FVC ratio (80.03 ± 5.52%) compared to other groups; however, there were no significant differences between groups. Bivariate correlation analysis showed that HbA1c was negatively related to FVC (L) (r = - 0.465, p = .002 [low]), FVC% prev. (r = -0.377, p = .016 [low]), and FEV1 (L) (r = -0.375, p = .017 [low]) but not to PFE and FEV1/FVC (p > .05). Our results suggest that HbA1c (%) level is associated with lower FVC and FEV1 in middle-aged adults, which may be a potential predictor of poor lung function.
- Subjects
MIDDLE-aged persons; GLYCOSYLATED hemoglobin; PEARSON correlation (Statistics); BIVARIATE analysis; ONE-way analysis of variance
- Publication
Journal of Human Sport & Exercise, 2024, Vol 19, Issue 1, p339
- ISSN
1988-5202
- Publication type
Article
- DOI
10.14198/jhse.2024.191.20