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- Title
The incidence of hypothyroidism in patients of head and neck carcinoma treated with radiotherapy and added risk of hypothyroidism with the addition of chemotherapy.
- Authors
Singh, Dharmendra; Roy, Niladri; Pal, Suparna Kanti; Basu, Siddhartha; Meyur, Suman
- Abstract
Background: Head and neck cancer (HNC) is the most common malignancy in the Indian males. Most of the cases of HNC present in locally advanced stage and requires a multidisciplinary management approach. Radical or adjuvant external beam radiotherapy (EBRT) is one of the important integral components of the management of HNC. Aim: To find the incidence of hypothyroidism (HT) in patients of HNC treated with radiotherapy with or without concurrent chemotherapy. Methods: A prospective, single institutional longitudinal observational study conducted at the department of radiotherapy, Institute of Post Graduate Medical Education and Research, Kolkata. Results: In this study, data of 118 patients were analysed. The median age at presentation was 56 years. The most common primary site of malignancy was oral cavity (39%). The patients were stage I, stage II and stage III as 11, 37·3 and 51·7% respectively. The median dose of EBRT was 66 Gy. HT statistically significantly correlated with primary site of malignancy (p = 0·001), dose of EBRT (p = 0·005). At the end of follow-up of 6 months, 39·8% developed HT. Conclusion: The thyroid gland is an important organ at risk while considering EBRT to neck region. The inclusion of thyroid function test in routine follow-up is mandated.
- Subjects
INDIA; THYROID gland function tests; HYPOTHYROIDISM; MOUTH tumors; CANCER chemotherapy; HEAD &; neck cancer; METASTASIS; RISK assessment; CANCER patients; DESCRIPTIVE statistics; LONGITUDINAL method; DISEASE risk factors
- Publication
Journal of Radiotherapy in Practice, 2022, Vol 21, Issue 1, p14
- ISSN
1460-3969
- Publication type
Article
- DOI
10.1017/S1460396920000692