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- Title
TISSUE DISTRIBUTION OF B-LYMPHOCYTE SUBSETS (IGA, IGG AND IGM) IN THE MUCOSA AND LYMPHOID TISSUES OF BROILERS IMMUNIZED WITH GUMBORO VACCINE.
- Authors
Hussan, M. T.; Khan, M. Z. I.; Jahan, M. R.
- Abstract
The present research was designed to study the histological and immunohistochemical changes of lymphoid (bursa of Fabricius and cecal tonsil) and mucosal (ileum) tissues of broiler chickens after immunization with Gumboro vaccine. Two groups (n=24) of Cobb-500 broiler chickens were reared in the same environment. A mild vaccine (BUR® 706) followed by an intermediate plus (Nobilis®Gumboro 228 E) vaccine was administered for immunization of chickens and samples (bursa of Fabricius, cecal tonsil and ileum) were collected at 7 days interval for up to 32 days of age. In the bursa of Fabricius, the population of lymphocytes and the size of the follicles were found to increase in vaccinated chickens than the control chickens. The Igs positive cells (IgA, IgG and IgM) were distributed principally beneath the capsule, around the follicles and in the cortex and medulla of bursa of Fabricius. The frequencies of IgG- and IgM- positive cells were intense than the IgApositive cells in the bursa of Fabricius vaccinated chickens. IgM-positive cells became peak at day 25 and started to decline at day 32 in the bursa of Fabricius of vaccinated groups of chickens. In the cecal tonsils and ileum, the Igs positive cells (IgA, IgG and IgM) were distributed around the intestinal gland and within the lymphatic nodules of the lamina propria, in the core of the villi, and within the epithelium in both the control and vaccinated chickens. Their frequency per 0.1 mm2 area of the lamina propria and in the epithelium was increased abruptly in the vaccinated group than the control broiler chickens. Like bursa, in the cecal tonsil and ileum of vaccinated chickens, the frequencies of IgG- and IgM-positive cells were also abundant than IgA-positive cells. The present study suggested that the Igs positive cells were greatly accelerated in the vaccinated chickens than the control chickens and it may be due to immunomodulatory effect of vaccine.
- Subjects
IMMUNIZATION; BROILER chicken diseases; VACCINES; IMMUNOGLOBULIN G; IMMUNOGLOBULIN A; IMMUNOGLOBULIN M; VACCINATION
- Publication
Bangladesh Journal of Veterinary Medicine, 2013, Vol 11, Issue 1, p13
- ISSN
1729-7893
- Publication type
Article