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- Title
Six Year Old with Autoimmune Polyglandular Syndrome: Can Genetics Tell Us the Story?
- Authors
Ghanny, Steven; Wallerstein, Robert; Chartoff, Amy; Post, Janet; Aisenberg, Javier; Auyeung, Valerie
- Abstract
The article discusses the case of a 6-year-old boy who has diabetes mellitus type 1 (DMT1), admitted to the emergency room with a 2-day history of diarrhea, vomiting and lethargy. The boy was presented in adrenal crisis and subsequently diagnosed with Addison's disease. It identifies HLA-DRB1 404/DR4 gene as one factor involved in the development of Addison's disease in children with DMT1. It proposes the use of genetic testing of associated human leukocyte antigen (HLA) haplotypes to screen children with DMT1.
- Subjects
DIABETES in children; DIARRHEA in children; VOMITING in children; ADDISON'S disease; HUMAN chromosome abnormality diagnosis; HLA histocompatibility antigens
- Publication
Journal of Pediatric Endocrinology & Metabolism, 2010, Vol 23, Issue 7, p725
- ISSN
0334-018X
- Publication type
Article
- DOI
10.1515/JPEM.2010.23.7.725