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- Title
Advances in research on early brain injury and therapeutic options for neuroprotection following subarachnoid hemorrhage.
- Authors
SONG Jin-ning; AN Ji-yang
- Abstract
Early brain injury (EBI) and delayed cerebral injury following subarachnoid hemorrhage (SAH) are closely associated with poor prognois in patients. Studies on the molecular mechanisms of EBI have revealed several pathological mechanisms involved in neurovascular dysfunction. These mechanisms include microvascular changes, altered ionic homeostaiis, blood-brain barrier disruption, inflammation, oxidative stress, and cell death pathway activation. These studies also provide multiple possible intervention targets for protecting neurological function after SAH, in which calcium channel blockers, endothelin-1 antagonism, anti-platelet agents, anti-inflammatory agents, and antioxidants may have neuroprotective effects agaimt EBI. Further elaborating on the molecular mechanisms of SAH-induced hypoxic-ischemic brain injury, neuroinflammation, cortical spreading depression, neuronal cell death and revealing the evolvement of these complex pathophysiological proceises are of great significance for reducing brain injury after SAH, promoting nerve repair, and ameliorating patients' quahty of life and overall mortahty.
- Subjects
BRAIN injuries; DRUG therapy; NEUROPROTECTIVE agents; SUBARACHNOID hemorrhage; CEREBRAL arteries; MOLECULAR models; BLOOD-brain barrier; WOUNDS &; injuries
- Publication
Journal of Xi'an Jiaotong University (Medical Sciences), 2013, Vol 34, Issue 6, p695
- ISSN
1671-8259
- Publication type
Article
- DOI
10.7652/jdyxb201306001