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Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model.
- Published in:
- 2008
- By:
- Publication type:
- journal article
Asymmetric Dearomatization/Cyclization Enables Access to Polycyclic Chemotypes.
- Published in:
- European Journal of Organic Chemistry, 2016, v. 2016, n. 28, p. 4800, doi. 10.1002/ejoc.201601003
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- Publication type:
- Article
Synthesis and Multiplexed Activity Profiling of Synthetic Acylphloroglucinol Scaffolds.
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- Angewandte Chemie International Edition, 2021, v. 60, n. 3, p. 1263, doi. 10.1002/anie.202010338
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- Publication type:
- Article
Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids.
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- Angewandte Chemie International Edition, 2020, v. 59, n. 52, p. 23772, doi. 10.1002/anie.202011171
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- Publication type:
- Article
Biomimetic Synthesis of Meroterpenoids by Dearomatization‐Driven Polycyclization.
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- Angewandte Chemie International Edition, 2019, v. 58, n. 45, p. 16141, doi. 10.1002/anie.201910710
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- Publication type:
- Article
Biomimetic Synthesis of Meroterpenoids by Dearomatization‐Driven Polycyclization.
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- Angewandte Chemie International Edition, 2019, v. 58, n. 45, p. 16141, doi. 10.1002/anie.201910710
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- Publication type:
- Article
Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate.
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- Angewandte Chemie International Edition, 2019, v. 58, n. 13, p. 4291, doi. 10.1002/anie.201814421
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- Publication type:
- Article
Total Synthesis of Aurofusarin: Studies on the Atropisomeric Stability of Bis‐Naphthoquinones.
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- Angewandte Chemie International Edition, 2018, v. 57, n. 8, p. 2101, doi. 10.1002/anie.201711535
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- Publication type:
- Article
Total Syntheses of the Isomeric Aglain Natural Products Foveoglin A and Perviridisin B: Selective Excited-State Intramolecular Proton-Transfer Photocycloaddition.
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- Angewandte Chemie International Edition, 2017, v. 56, n. 46, p. 14479, doi. 10.1002/anie.201707539
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- Publication type:
- Article
Synthesis and Multiplexed Activity Profiling of Synthetic Acylphloroglucinol Scaffolds.
- Published in:
- Angewandte Chemie, 2021, v. 133, n. 3, p. 1283, doi. 10.1002/ange.202010338
- By:
- Publication type:
- Article
Exploiting the Potential of Meroterpenoid Cyclases to Expand the Chemical Space of Fungal Meroterpenoids.
- Published in:
- Angewandte Chemie, 2020, v. 132, n. 52, p. 23980, doi. 10.1002/ange.202011171
- By:
- Publication type:
- Article
Biomimetic Synthesis of Meroterpenoids by Dearomatization‐Driven Polycyclization.
- Published in:
- Angewandte Chemie, 2019, v. 131, n. 45, p. 16287, doi. 10.1002/ange.201910710
- By:
- Publication type:
- Article
RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer.
- Published in:
- Nature, 2014, v. 513, n. 7516, p. 65, doi. 10.1038/nature13485
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- Publication type:
- Article
Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia.
- Published in:
- BMC Pharmacology & Toxicology, 2013, v. 14, n. 1, p. 1, doi. 10.1186/2050-6511-14-58
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- Publication type:
- Article
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma.
- Published in:
- Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-13086-5
- By:
- Publication type:
- Article
Asymmetric, Stereodivergent Synthesis of (−)-Clusianone Utilizing a Biomimetic Cationic Cyclization.
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- Angewandte Chemie International Edition, 2014, v. 53, n. 30, p. 7832, doi. 10.1002/anie.201404437
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- Publication type:
- Article
Total Syntheses of Secalonic Acids A and D.
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- Angewandte Chemie International Edition, 2014, v. 53, n. 12, p. 3107, doi. 10.1002/anie.201311260
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- Publication type:
- Article
Biomimetic Dehydrogenative Diels-Alder Cycloadditions: Total Syntheses of Brosimones A and B.
- Published in:
- Angewandte Chemie International Edition, 2013, v. 52, n. 32, p. 8345, doi. 10.1002/anie.201302847
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- Publication type:
- Article
Development of an Alkaloid-Pyrone Annulation: Synthesis of Pleiomaltinine.
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- Angewandte Chemie International Edition, 2012, v. 51, n. 37, p. 9348, doi. 10.1002/anie.201204093
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- Publication type:
- Article
Asymmetric Total Synthesis of the Epoxykinamycin FL-120 B′.
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- Angewandte Chemie International Edition, 2011, v. 50, n. 41, p. 9722, doi. 10.1002/anie.201104504
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- Publication type:
- Article
Sequential Transformations to Access Polycyclic Chemotypes: Asymmetric Crotylation and Metal Carbenoid Reactions.
- Published in:
- Angewandte Chemie International Edition, 2011, v. 50, n. 26, p. 5938, doi. 10.1002/anie.201101366
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- Publication type:
- Article
Dearomatization Strategies in the Synthesis of Complex Natural Products.
- Published in:
- Angewandte Chemie International Edition, 2011, v. 50, n. 18, p. 4068, doi. 10.1002/anie.201006017
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- Publication type:
- Article
Synthesis and Biological Evaluation of ABCD Ring Fragments of the Kibdelones.
- Published in:
- Angewandte Chemie International Edition, 2011, v. 50, n. 11, p. 2511, doi. 10.1002/anie.201007613
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- Publication type:
- Article
Biomimetic Photocycloaddition of 3-Hydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation.
- Published in:
- Angewandte Chemie International Edition, 2010, v. 49, n. 37, p. 6533, doi. 10.1002/anie.201003212
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- Publication type:
- Article
Streamlined synthesis of substituted 2-Aminothiazoles using tandem precipitative and polymer-assisted reactions.
- Published in:
- Biotechnology & Bioengineering, 2000, v. 71, n. 1, p. 9, doi. 10.1002/(SICI)1097-0290(200024)71:1<9::AID-BIT3>3.0.CO;2-#
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- Publication type:
- Article
Polymer supports for streamlined organic synthesis.
- Published in:
- Biotechnology & Bioengineering, 2000, v. 71, n. 1, p. 1, doi. 10.1002/(SICI)1097-0290(200024)71:1<1::AID-BIT1>3.0.CO;2-T
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- Publication type:
- Article
Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines.
- Published in:
- Molecules, 2015, v. 20, n. 5, p. 7474, doi. 10.3390/molecules20057474
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- Publication type:
- Article
Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs.
- Published in:
- Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-35908-0
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- Publication type:
- Article
Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma.
- Published in:
- Cells (2073-4409), 2021, v. 10, n. 2, p. 301, doi. 10.3390/cells10020301
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- Publication type:
- Article
Total Synthesis of the Salicylate Enamide Macrolide Oximidine III: Application of Relay Ring-Closing MetathesisWe thank Prof. Y. Hayakawa (Tokyo University of Science) for kindly providing an authentic sample of oximidine III, Dr. J. Lee (Boston University) for assistance with NMR spectroscopy, and Mr. R. Shen (Boston University) for helpful suggestions. We thank the National Institutes of Health (Grant no. GM-62842) for research support.
- Published in:
- Angewandte Chemie, 2004, v. 116, n. 27, p. 3685, doi. 10.1002/ange.200460042
- By:
- Publication type:
- Article
Synthesis of Azaphilones and Related Molecules by Employing Cycloisomerization of o-Alkynylbenzaldehydes ( We thank Dr. Takafumi Kohama (Sankyo Co. LTD.) for providing <sup>1</sup>H and <sup>13</sup>C NMR spectra of S-15183a and Dr. Emil Lobkovsky (Cornell University) for X-ray crystal structure analysis. We thank CEM Corporation (Matthews, NC) for providing the Explorer microwave system, Bristol-Myers Squibb for an unrestricted Grant in Synthetic Organic Chemistry (J.A.P, Jr.), and Novartis Pharma AG for research support. )
- Published in:
- Angewandte Chemie, 2004, v. 116, n. 10, p. 1259, doi. 10.1002/ange.200353037
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- Publication type:
- Article
Total Synthesis of the Ubiquitin-Activating Enzyme Inhibitor (+)-Panepophenanthrin ( We thank Chaomin Li for helpful discussions, Dr. Ryuichi Sekizawa (Showa Pharmaceutical University) for providing authentic panepophenanthrin, and Dr. Emil Lobkovsky (Cornell University) for X-ray crystal structure analysis. Financial support from the American Cancer Society (RSG-01-135-01, J.A.P, Jr.) and the NIH (P50 GM067041) is gratefully acknowledged. R.P.J. acknowledges the Norman and Anna S. Waite Professorship for support. )
- Published in:
- Angewandte Chemie, 2003, v. 115, n. 33, p. 4043, doi. 10.1002/ange.200351862
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- Publication type:
- Article
Advancing Science through Synthetic Chemistry and Chemical Biology: Special Issue in Honor of the 2016 Wolf Prize Laureates in Chemistry, Professors Kyriacos C. Nicolaou and Stuart L. Schreiber.
- Published in:
- 2017
- By:
- Publication type:
- Editorial
Drug-induced Stress Granule Formation Protects Sensory Hair Cells in Mouse Cochlear Explants During Ototoxicity.
- Published in:
- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-48393-w
- By:
- Publication type:
- Article
Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation.
- Published in:
- Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-018-37666-5
- By:
- Publication type:
- Article
Enantioselective Synthesis of (+)-Chamaecypanone C: A Novel Microtubule Inhibitor.
- Published in:
- Angewandte Chemie International Edition, 2009, v. 48, n. 8, p. 1494, doi. 10.1002/anie.200805486
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- Publication type:
- Article
Enantioselective Synthesis of the Complex Rocaglate (−)-Silvestrol.
- Published in:
- Angewandte Chemie International Edition, 2007, v. 46, n. 41, p. 7831, doi. 10.1002/anie.200702707
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- Publication type:
- Article
Nucleophilic Addition to N-Phosphinylimines by Rare-Earth-Metal Triflate/Trifluoroacetic Anhydride Activation.
- Published in:
- Angewandte Chemie International Edition, 2007, v. 46, n. 39, p. 7470, doi. 10.1002/anie.200700694
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- Publication type:
- Article
Synthesis of the Tetracyclic Core of the Tetrapetalones through Transannular Oxidative [4+3] Cyclization.
- Published in:
- Angewandte Chemie International Edition, 2006, v. 45, n. 40, p. 6607, doi. 10.1002/anie.200690139
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- Publication type:
- Article
Total Synthesis and Structure Assignment of (+)-HexacyclinolWe thank Mr. Andrew Germain (Boston University) for helpful discussions, Dr. Friedrich A. Gollmick (Leibniz Institute for Natural Products Research and Infection Biology—Hans-Knöll-Institute, Jena, Germany) for providing spectra of natural hexacyclinol, and Dr. Emil Lobkovsky (Cornell University) for X-ray crystal structure analysis. Financial support from the NIH (GM62842 and P50 GM067041), Bristol-Myers Squibb, Merck, and Novartis is gratefully acknowledged.
- Published in:
- Angewandte Chemie International Edition, 2006, v. 45, n. 35, p. 5790, doi. 10.1002/anie.200602854
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- Publication type:
- Article
A μ-η2:η2-Disulfide Dicopper(II) Complex from Reaction of S8 with a Copper(I) Precursor: Reactivity of the Bound Disulfur MoietyK. D. Karlin is grateful to the US National Institute of Health (NIH, GM 28962) for financial support of the research. M. E. Helton acknowledges support from the NIH for a postdoctoral fellowship. We also acknowledge Dr. Andreas Heutling (Boston University) for carrying out preliminary studies.
- Published in:
- Angewandte Chemie International Edition, 2006, v. 45, n. 7, p. 1138, doi. 10.1002/anie.200503216
- By:
- Publication type:
- Article
Synthesis of the Tetracyclic Core of the Tetrapetalones through Transannular Oxidative [4+3] CyclizationWe thank Dr. J. Lee (Boston University) for assistance with NMR experiments and the National Institutes of Health (GM-62842) for research support.
- Published in:
- Angewandte Chemie International Edition, 2005, v. 44, n. 20, p. 3067, doi. 10.1002/anie.200500247
- By:
- Publication type:
- Article
Total Synthesis of the Salicylate Enamide Macrolide Oximidine III: Application of Relay Ring-Closing Metathesis.
- Published in:
- Angewandte Chemie International Edition, 2004, v. 43, n. 27, p. 3601, doi. 10.1002/anie.200460042
- By:
- Publication type:
- Article
Synthesis of Azaphilones and Related Molecules by Employing Cycloisomerization of o-Alkynylbenzaldehydes ( We thank Dr. Takafumi Kohama (Sankyo Co. LTD.) for providing <sup>1</sup>H and <sup>13</sup>C NMR spectra of S-15183a and Dr. Emil Lobkovsky (Cornell University) for X-ray crystal structure analysis. We thank CEM Corporation (Matthews, NC) for providing the Explorer microwave system, Bristol-Myers Squibb for an unrestricted Grant in Synthetic Organic Chemistry (J.A.P, Jr.), and Novartis Pharma AG for research support. )
- Published in:
- Angewandte Chemie International Edition, 2004, v. 43, n. 10, p. 1239, doi. 10.1002/anie.200353037
- By:
- Publication type:
- Article
How proteins bind macrocycles.
- Published in:
- Nature Chemical Biology, 2014, v. 10, n. 9, p. 723, doi. 10.1038/nchembio.1584
- By:
- Publication type:
- Article
Analysis of 9-fluorenylmethoxycarbonyl (FMOC) loading of solid-phase synthesis resins by gas chromatography.
- Published in:
- Biotechnology & Bioengineering, 1998, v. 61, n. 1, p. 55, doi. 10.1002/(SICI)1097-0290(199824)61:1<55::AID-BIT10>3.0.CO;2-8
- By:
- Publication type:
- Article
An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris.
- Published in:
- Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-20183-3
- By:
- Publication type:
- Article
Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer.
- Published in:
- Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-20054-x
- By:
- Publication type:
- Article
Development of an Alkaloid-Pyrone Annulation: Synthesis of Pleiomaltinine.
- Published in:
- Angewandte Chemie, 2012, v. 124, n. 37, p. 9482, doi. 10.1002/ange.201204093
- By:
- Publication type:
- Article
Asymmetric Total Synthesis of the Epoxykinamycin FL-120 B′.
- Published in:
- Angewandte Chemie, 2011, v. 123, n. 41, p. 9896, doi. 10.1002/ange.201104504
- By:
- Publication type:
- Article