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- Title
Effect of Variable Kisspeptin Doses on Prostatic Citric Acid Levels in Male Mice.
- Authors
Ramzan, Faiqah; Ramzan, Muhammad Haris
- Abstract
Kisspeptin, a product of the KISS1 gene, plays an essential role in the regulation of spermatogenesis acting primarily at the hypothalamic level of the gonadotropic axis. Citric acid is synthesized and secreted by the prostate gland. Its synthesis is regulated by androgens. As, dose dependent degeneration of prostate gland has been described following intraperitoneal kisspeptin treatment. However, effects of kisspeptin administration on the levels of prostatic citric acid remain elusive till date. The present study, therefore, addresses the effects of 12 day administration of kisspeptin on prostatic citric acid levels in male mice. Kisspeptin-10 was administered intraperitoneally in different dosage concentrations (1μg, 1 ng, and 10 ρg) to adult male mice twice daily for 12 days. Prostatic citric acid levels were determined photometrically. The levels decreased significantly at all tested doses. Intermittent administration of Kisspeptin -10 negatively regulates the prostatic citric acid levels in adult male mice.
- Subjects
KISSPEPTIN neurons; PROSTATE; CITRIC acid; SPERMATOGENESIS; ANDROGENS
- Publication
Pakistan Journal of Zoology, 2017, Vol 49, Issue 1, p355
- ISSN
0030-9923
- Publication type
Article
- DOI
10.17582/journal.pjz/2017.49.1.sc2