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- Title
Hyperuricemia and gout in solid-organ transplant: update in pharmacological management.
- Authors
Sullivan, Peter M.; William, Asch; Tichy, Eric M.
- Abstract
Hyperuricemia is a common comorbid condition experienced by up to 28% of kidney transplant recipients. These patients are at elevated risk of acute flare-ups of gout because of transplant-specific risk factors such as impaired renal function, chronic contributing pharmacotherapy (eg, calcineurin inhibitors, diuretics), and associated comorbid conditions. After transplant, treatment is often complicated by drug-drug interactions, renal impairment, and toxic effects of drugs with the use of first-line recommended agents. A number of therapeutic options remain available for transplant recipients, including dose modifications of historic agents and newer pharmacotherapeutic options. Notably, the Kidney Disease Improving Global Outcomes guidelines address the management of hyperuricemia and gout, but these guidelines were last published in 2009, and new data and treatment options have emerged since then. The management of hyperuricemia and acute and chronic gout is described, including the use of novel agents including urate oxidases, interleukin 1 inhibitors, and human urate transporter 1 inhibitors and alternative immunosuppressive therapy strategies.
- Subjects
COLCHICINE; DISEASE relapse; OXIDOREDUCTASES; PROBENECID (Drug); ALLOPURINOL; BELATACEPT; SULFINPYRAZONE; DRUG interactions; HYPERURICEMIA; GOUT; INTERLEUKINS; KIDNEY transplantation; COMORBIDITY; CHEMICAL inhibitors; DISEASE complications; DISEASE risk factors; THERAPEUTICS
- Publication
Progress in Transplantation, 2015, Vol 25, Issue 3, p263
- ISSN
1526-9248
- Publication type
Article
- DOI
10.7182/pit2015322