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- Title
Ocular Mycosis.
- Authors
Uno, Toshihiko
- Abstract
Fungi causing human keratitis take the form either yeasts or mold. Candida, the major pathogenic yeasts, can be detected in the normal ocular surface flora. Preceding ocular surface disorder, the wearing of contact lenses and the use of antibiotic/steroid eye drops may lead to candida keratitis. Infectious focus caused by Candida tends to melt the corneal stroma. Keratitis caused by mold often develops after an injury caused by soil and/or a plant. Mold can reach the anterior chamber without destroying the stromal layer of the cornea, which results in distinctive clinical features such as endothelial plaque and hyphate ulcer. Fungal keratitis needs to be managed by antifungal agents, most of which must be prepared by ourselves to apply to the ocular surface. Candida keratitis should be managed with azoles. If the infection seems to be caused by mold, several antifungal drugs including pimaricin, which is the only agent officially applicable to the eye , should be used. Some cases of mold keratitis need to have therapeutic penetrating keratoplasty because of their lack of response to intensive medication. Mold causing keratitis is variegated. Fusarium and Aspergillus can be reach the intraocular space rapidly. Alternaria and some progress of focus in the cornea is regulated by the receptiveness of mold against temperature.
- Subjects
KERATITIS; CORNEA diseases; CANDIDA; ANTIFUNGAL agents; MYCOSES; FUSARIUM; ASPERGILLUS; MYCOLOGY
- Publication
Japanese Journal of Medical Mycology, 2008, Vol 49, Issue 3, p175
- ISSN
0916-4804
- Publication type
Article
- DOI
10.3314/jjmm.49.175