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- Title
Lymphocyte-Selective Antiproliferative and Immunosuppressive Effects of Mycophenolic Acid in Mice.
- Authors
Eugui, E. M.; Mirkovich, A.; Allison, A. C.
- Abstract
Mycophenolic acid (MPA), administered orally to mice, inhibits the formation of antibodies to sheep erythrocytes. MPA also suppresses, in a dose-related manner, the generation of cytotoxic T-lymphocytes against allogeneic cells in mice and prevents the elimination of allogeneic cells. However, short-term treatment of T lymphocytes with therapeutically attainable doses of MPA does not inhibit the effector phase of cytotoxicity. Doses of MPA sufficient to prevent allograft rejection in mice inhibit the incorporation of labelled thymidine into DNA in the lymph nodes and spleen of mice but not in the germinal cells of the testis or in the basal epithelial cells of the Jejunum; they do not produce neutropienia, anaemia or thrombocylopcnia. These observations show that MPA has lymphocyte-selective anti-proiiferative effects in vivo and can inhibit both cell-mediated and humoral immune responses without major side effects. Reasons why MPA has advantages over currently used and recently identified immunosuppressive drugs are discussed. The experimental system described provides a convenient in vivo assay For the capacity of drugs to inhibit allograft rejection.
- Subjects
DRUG interactions; LEUCOCYTES; LYMPHOCYTES; BLOOD cells; NUCLEIC acids; LYMPH nodes
- Publication
Scandinavian Journal of Immunology, 1991, Vol 33, Issue 2, p175
- ISSN
0300-9475
- Publication type
Article
- DOI
10.1111/j.1365-3083.1991.tb03747.x