We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Reflux Disease and Proton Pump Inhibitor Therapy: Impact upon Sleep Disturbance.
- Authors
Regenbogen, Elliot; Helkin, Alex; Georgopoulos, Rachel; Vasu, Tajender; Shroyer, A. Laurie W.
- Abstract
Objective: To perform a systematic literature review that evaluates the impact of proton pump inhibitor treatment of gastroesophageal reflux disease upon sleep disturbance‐related outcomes. Method: PubMed, Web of Science, and Cochrane databases were searched from 1989 to present, identifying all radomized placebo‐controlled clinical trials where both proton pump inhibitor use and outcome measures of sleep disturbance were reported for esophageal refludisease patients. Using pre‐established systematic review protocol 4 co‐authors independently reviewed all articles. Results: The original search idetified 20 articles; 9 were not directly relevant, and 3 were not placebo controlled. Sample sizes varied from 15 to 642; mean age was 47.4 ± 4.56; mean body mass index was 29.4 ± 2.90; the proportion of women varied widely across studies. Esopmeprazole was studied most frequently. Over 50% of publications permitted rescue antacids. Two studies reported polysomnography outcomes, without statistically significant improvement. All studies reported nonpolysomnography outcomes; 7 identified statistically significant improvements demonstrating drug treatment superiority over placebo. Conclusion: The existing evidence supports the use of proton pump inhibitor as a treatment for esophageal reflux disease to improve quality of life sleep disturbance‐related outcomes. While variability in treatments and outcomes prevented direct comparisons, this conclusion appears robust for 7 of 8 studies, including the highest 3 quality studies.
- Publication
Otolaryngology-Head & Neck Surgery, 2012, Vol 145, Issue 2, pP122
- ISSN
0194-5998
- Publication type
Article
- DOI
10.1177/0194599812451438a273