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- Title
Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism.
- Authors
Huber, Kimberly M.; Klann, Eric; Costa-Mattioli, Mauro; Suzanne Zukin, R.
- Abstract
The mammalian target of rapamycin (mTOR) is a central regulator of a diverse array of cellular processes, including cell growth, proliferation, autophagy, translation, and actin polymerization. Components of themTORcascade are present at synapses and influence synaptic plasticity and spine morphogenesis. A prevailing view is that the study of mTOR and its role in autism spectrum disorders (ASDs) will elucidate the molecular mechanisms by which mTOR regulates neuronal function under physiological and pathological conditions. Although many ASDs arise as a result of mutations in genes with multiple molecular functions, they appear to converge on common biological pathways that give rise to autism-relevant behaviors. Dysregulation of mTOR signaling has been identified as a phenotypic feature common to fragile X syndrome, tuberous sclerosis complex 1 and 2, neurofibromatosis 1, phosphatase and tensin homolog, and potentially Rett syndrome. Below are a summary of topics covered in a symposium that presents dysregulation ofmTORas a unifying theme in a subset of ASDs.
- Subjects
ANIMAL disease models; MICE behavior; LABORATORY mice; MTOR protein; DIAGNOSIS of fragile X syndrome; AUTISM spectrum disorders; PROTEIN synthesis; IMMUNOSUPPRESSIVE agents
- Publication
Journal of Neuroscience, 2015, Vol 35, Issue 41, p13836
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.2656-15.2015