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- Title
Haemoglobin concentration and the risk of death in older adults: differences by race/ethnicity in the NHANES III follow-up.
- Authors
Patel, Kushang V.; Longo, Dan L.; Ershler, William B.; Yu, Binbing; Semba, Richard D.; Ferrucci, Luigi; Guralnik, Jack M.
- Abstract
Mildly low haemoglobin concentration is associated with increased mortality in older adults. However, this relationship has not been well characterized in racial/ethnic minorities. Therefore, this study determined the haemoglobin threshold below which risk of death is significantly increased in older non-Hispanic whites, non-Hispanic blacks, and Mexican Americans. Data on 4089 participants of the 1988–94 US National Health and Nutrition Examination Survey who were ≥65 years of age were analyzed with mortality follow-up through December 31, 2000. Mean haemoglobin in non-Hispanic whites ( n = 2686) and Mexican Americans ( n = 663) was 140 g/l, while in non-Hispanic blacks ( n = 740) the mean was 10 g/l lower. A total of 1944 (47·5%) participants died. Among non-Hispanic whites and Mexican Americans, age- and sex-adjusted models showed that the haemoglobin thresholds below which mortality risk was significantly increased were 4 and 2 g/l respectively, above the World Health Organization (WHO) cut-off points for anaemia. In contrast, the threshold for non-Hispanic blacks was 7 g/l below the WHO criteria. Similar threshold effects were observed when analyzing haemoglobin in categories and adjusting for multiple confounders. In conclusion, the haemoglobin threshold below which mortality rises significantly is a full g/dl lower in non-Hispanic blacks than in non-Hispanic whites and Mexican Americans.
- Subjects
HEMOGLOBINS; ANEMIA; NUTRITION surveys; AGING; HEALTH &; race
- Publication
British Journal of Haematology, 2009, Vol 145, Issue 4, p514
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/j.1365-2141.2009.07659.x