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- Title
Molecular cytogenetics characterization of a novel translocation involving chromosomes 17 and 19 in a Ph<sup>+</sup> adult acute lymphoblastic leukaemia.
- Authors
Specchia, Giorgina; Albano, Francesco; Anelli, Luisa; Storlazzi, Clelia Tiziana; Cimino, Giuseppe; Liso, Arcangelo; Zagaria, Antonella; Liso, Vincenzo; Rocchi, Mariano
- Abstract
Summary. We report a case of positive Philadelphia chromosome adult acute lymphoblastic leukaemia with a novel unbalanced translocation t(17;19), leading to trisomy of 17q21-qter. The patient did not obtain complete haematological response and died a few months after diagnosis. The significance of the 17q21-qter trisomy, resulting from this novel translocation, and its possible role in the progression of the leukaemia is discussed.
- Subjects
LYMPHOBLASTIC leukemia; CHROMOSOMAL translocation; TRISOMY; GENETICS
- Publication
British Journal of Haematology, 2002, Vol 119, Issue 2, p488
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2002.03846.x