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- Title
NHC‐Catalyzed C3‐Acylation of 2‐Oxindoles by Selective Aerobic Oxidation of Aryl Aldehydes.
- Authors
Muthuvel, Karthick; Gandhi, Thirumanavelan
- Abstract
We here report an effective NHC‐catalyzed acylation of 2‐oxindoles using aldehydes with the aid of aerobic oxidation to prepare 3‐alkylideneoxindoles ‐ a biologically active moiety. This protocol is the first report on the use of oxidized Breslow intermediate for the carbon nucleophile and applies to a wide variety of aryl aldehydes, cyclohexanal, and metallocene‐aldehyde. Lower catalyst loading, milder base, greener oxidant, easily available substrates, and ambient reaction temperature exemplify this as a sustainable methodology.
- Subjects
ALDEHYDES; OXIDATION; OXIDIZING agents; ALCOHOL oxidation; MOIETIES (Chemistry); OXINDOLES; ACYLATION
- Publication
Asian Journal of Organic Chemistry, 2024, Vol 13, Issue 2, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202300599