We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Asymmetric Direct Vinylogous Conjugate Addition of Substituted Furanone Derivatives to (E)‐ and (Z)‐Benzoyl Acrylonitriles Using Organocatalysts.
- Authors
Ishii, Daiki; Hirashima, Shin‐ichi; Akutsu, Hiroshi; Nakashima, Kosuke; Matsushima, Yasuyuki; Sakai, Takaaki; Miura, Tsuyoshi
- Abstract
Diaminomethylenemalononitrile organocatalysts efficiently promoted the asymmetric direct vinylogous conjugate addition of α‐angelica lactone to (E)‐ and (Z)‐benzoyl acrylonitrile derivatives. The synthesized products bear vicinal tertiary and quaternary stereogenic centers with excellent enantioselectivities (up to 98% ee). This report is the first successful example of the stereoselective conjugate addition using (Z)‐benzoyl acrylonitriles as Michael acceptor.
- Subjects
ACRYLONITRILE; FURANONES; NITROALKENES; CARBONYL compounds
- Publication
Asian Journal of Organic Chemistry, 2022, Vol 11, Issue 5, p1
- ISSN
2193-5807
- Publication type
Article
- DOI
10.1002/ajoc.202200048